Objective The goal of this research project is to study and develop novel synergistic technologies for the next generation of high performance biochips, for future applications e.g. in accelerated drug discovery, diagnostics and personalized medicine. One of the key technologies relies on a predictable self-organization of fluids, using both static and dynamic formats will be utilized. The formats will be combined to overcome current bottlenecks in the automation of high throughput assays, and will also be used for the development of a new concept for automated chip replication. Other complementary technologies deal with surface-expanded high-density bio probe arrays, including the use of novel polymers. Also, novel magnetic bio Nan wires, controlled by an external magnetic field onto a platform of magnetic handouts, will be explored. It is anticipated that the use of these technologies will provide unique possibilities to increase legend density, as well as enhanced kinetics, resulting in enhanced sensitivity and faster assay performance. A third technology based on externally applied surface acoustic waves will be incorporated into the platform, yielding extremely efficient agitation of Nan droplets. Finally, a Nan electrochemical detection system will be developed. The technologies will be combined to yield an optimised Nan array chip, including the novel fluid agitation and bio-Nan wires principles. The optimised structure will be tested using standard bioassays, and the results obtained will be compared with performance data, obtained from similar experiments with state of the art biochips. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverysocial sciencessociologyindustrial relationsautomationnatural scienceschemical sciencespolymer sciencesmedical and health scienceshealth sciencespersonalized medicineengineering and technologynanotechnologynano-materials Keywords Nanotechnology biochip magnetic particles nanofluids nanopillars nanowires replication Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2002-3.4.1.1-2 - Self-organisation and self-assembling NMP-2002-3.4.1.2-1 - Interfaces between biological and non biological entities Call for proposal FP6-2002-NMP-1 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator KUNGLIGA TEKNISKA HOEGSKOLAN Address Valhallavaegen, 79 10044 Stockholm Sweden See on map EU contribution No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT CURIE France EU contribution € 0,00 Address 26, rue d'ulm Paris See on map Other funding No data NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN Germany EU contribution € 0,00 Address Markwiesenstrasse 55 Reutlingen See on map Other funding No data ECOLE NORMALE SUPERIEURE France EU contribution € 0,00 Address 45 rue d'ulm Paris See on map Other funding No data DIAGNOSWISS SA Switzerland EU contribution € 0,00 Address Route de l'ile-au-bois 2, c/o cimo s.a., case postale Monthey See on map Other funding No data ADVALYTIX AG Germany EU contribution € 0,00 Address Eugen-saenger-strasse 53 Brunnthal See on map Other funding No data
