Objective
In most individuals, the adipose tissue, like other adult tissues, maintains a stable mass. Nevertheless, this tissue displays a unique capacity to grow or regress during adulthood, when energy balance shifts positively or negatively. In humans, phenotypes of adipose dystrophy range from massive obesity, where adipose mass represents 60 to 70% of body weight, to lipoatrophy, with less than 2% of fat. Starting during the past 10-20 years, the number of obese individuals is increasing on an epidemic scale wor ld-wide. The clinical problem of excessive adipose tissue mass resides in its strong association with a number of life-threatening conditions: hyperlipidemia, high blood pressure, glucose intolerance and diabetes, coronary heart disease and some types of c ancers.The main cellular components of adipose tissue are adipocytes. It is now recognised that these cells are at the heart of a complex endocrine and paracrine network, which substantially influences the whole organism. Dysregulation of adipose cell mass induces profound alterations of the cell\'s metabolic properties and hormonal responsiveness, leading to alteration in adipose-derived circulating factors. These defects have been causally implicated in several obesity-related co-morbidities.We and others have recently revealed that adipose differentiation, metabolism and secretory function are sensitive to hypoxia and that Hypoxia Inducible Factor (HIF) activation underlies several ol these responses. Here, we propose to investigate the genomic and phenot ypic effects of modulation of HIF activity in the adipose cell. At the cellular level, the effect of genetic and pharmacological activation of the HIF system on adipose gene expression and metabolic activity will be studied in the mouse 3T3-L1 pre-adipose cell line. The physiological effects of manipulating HIF will also be investigated in transgenic mice with enhanced HIF activity specifically in the adipose tissue.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.