Objective
Despite intensive worldwide research efforts, cancer remains a devastating, often poorly treatable disease. We propose to develop and apply new functional genomics technologies that will provide unique approaches to the design of new pathway- specific cancer therapies. Our specific objectives are: 1)To develop large-scale functional genomic analysis to identify novel mechanisms involved in cancer development; specifically, we will generate the tools and technologies to carry out genome-wide loss-of-function screens in mammalian cells. 2)To apply these technologies to specific models of major human cancer-causing pathways to define novel targets for therapy. 3)To use existing and generate novel mouse models and non-invasive tumour imaging to validate and assay cancer gene function in vivo and to develop new treatment modalities. 4)To develop cell-based assays for cancer-relevant genes and pathways that will serve as readout for the identification of anticancer agents through the screening of chemical compound libraries. 5)To distribute and disseminate the novel technologies for the study of gene function in vitro and vivo within the consortium and to researchers in the European Community. To reach these objectives we have formed a multidisciplinary research consortium, including top scientists with extensive experience in developing innovative genomics technologies and with an excellent track-record in identifying key signalling molecules involved in cancer, as well as SMEs with experience in identifying cancer-relevant genes and in screening chemical compound libraries. The location of most of the partners at leading European cancer centers will ensure optimal conditions for the development of novel cancer-specific treatments. This proposal provides new possibilities of "Translating basic knowledge of functional oncogenomics into cancer diagnosis and treatment" in compliance with the main goal in the "LifeSciHealth" call in FP6.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2177 COPENHAGEN K
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.