Objective
The fragile X mental retardation syndrome is a genetic disease that results from the absence or a defect in the FMRP protein and is the most frequent cause of inherited mental retardation (1 in 4000 males and 1 in 7000 females). FMRP is found in the nucleu s and cell body of neurons as well as in their dendrites and synapses. Recent data suggests that the protein has a role in the regulation of translation, via a small non translated RNA called BC1. FMRP is part of a large mRNP complex and binds to proteins and RNA. Previous studies performed by the host group shown that FMRP itself is translated at the synapses. Further, its absence in knock-out mice significantly alters the translation efficiency of some mRNAs at the synapses. Since brain synapses are impli cated in learning, memory and cognition, the lack of translational regulation at the synapses may well be the cause for mental retardation in the fragile X syndrome, and it is most important to understand the function of FMRP at the synapses. In this proje ct, we will purify the FMRP complex from synaptosomal preparations and characterise the proteins and RNAs bound to the complex. The proposed project is focused to the understand the function of FMRP at the synapses through the identification of RNA and pro tein species to which FMRP binds within neuronal cells. This project will give an important contribution to the understanding of the Fragile X Syndrome. In addition, the data will yield interesting insights into the translational regulation at the synapses , thereby advancing our understanding of gene expression in the synapses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.