Objective
The aim of this project is to identify the common mechanisms in the generation of planar cell polarization (PCP) during the Drosophila wing development and during zebrafish gastrulation. Planar polarization of the Drosophila wing epithelium is reflected by the formation of a single actin-based hair at the distal tip of each cell. Components of the Wnt/Fz signalling pathway (PCP pathway) have been shown to control both the number and orientation of these hairs. Similarly, during vertebrate gastrulation, cell s become polarized and extend several actin-based filopodia in the direction of cell movement. PCP signalling likely controls polarized outgrowth of filopodia in these cells. While the general conservation of PCP signalling between Drosophila and zebrafish has been demonstrated, very little is known about the similarity of these two systems at the cellular and molecular level. To address this intriguing developmental question, we plan to conduct a comparative analysis of planar cell polarization in both sys tems. Initially, we will select components of the PCP pathway that have a conserved role in planar cell polarization in Drosophila and in zebrafish. We will focus specifically on new and previously identified genes in Drosophila with a critical role for bo th the orientation and number of wing hairs. Zebrafish homologues of these genes will be identified and tested for their potential role in gastrulation by conducting a morpholino-based loss-of function screen. Promising candidates will then be chosen for a detailed comparative analysis. Specifically, we will address at the single-cell level how the dynamic process of hair and filopodia formation is controlled in each system. Such a comparative study represents a modern approach of studying developmental cel l biology. It will extend our knowledae of how sianallina pathways are evolutionary conserved and how they are applied to different developmental contexts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DRESDEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.