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Closed Loop INsulin Infusion for Critically Ill Patients

Project description

eHealth Intelligent glucose monitoring

Devices to regulate the blood-sugar levels of critically ill patients in intensive care wards are set to improve treatment and even save lives when they go into commercial use in the coming years.

Developed by the CLINICIP project, the intelligent devices address a potentially fatal side effect of trauma and shock: rapid increases in the body’s glucose levels that intensive care unit (ICU) doctors and nurses have typically found hard to control.

As with diabetes, high glucose levels in trauma patients can be brought down through infusions of insulin. However, in an ICU environment the changes are often more rapid, and an excessive dose of insulin can lead to dangerously low blood sugar, a condition known as hypoglycaemia.

Controlling the risks of irregular blood sugar

The CLINICIP team saw where technology could come to the aid of ICU patients. Working in collaboration with several European hospitals, they developed and tested a device to support nurses in deciding how much insulin and how frequently to administer it, while also working towards a more advanced system that would automate insulin injections entirely.

The decision-support device, which is expected to be commercially available in 2009 after further trials, still relies on nurses drawing blood from patients and testing glucose levels in the traditional way.

However, instead of administering the insulin directly they input the glucose information into the device via a touch screen. A specially designed algorithm then calculates how much insulin is needed before administering it to the patient. The device alerts nurses when blood samples need to be taken, which can be as frequently as every half hour.

Using the system in trials, just one hypoglycaemic event was recorded in 434 ICU days.

Automatic insulin injections

The automated version of the system, which the project partners expect to make available commercially in 2011, goes one step further in order to minimise the need for nurses to intervene.

Using a glucose-monitoring interface and an insulin-infusion interface in a closed-loop system, the device draws blood samples from the patient automatically, calculates the insulin required to bring their blood sugar within normal levels, then administers the correct dose.

Improving patients’ chances of survival

Clinical trials in Europe have shown that such a device would probably dramatically improve the survival chances of critically ill patients who develop irregular glucose levels. Although hospitals frequently check blood sugar in ICU patients, few have implemented tight controls because of the risks of overcompensating and the need to have more nursing staff dedicated to glucose control.

CLINICIP’s automated system overcomes both those problems, while its decision-support device reduces the risks of nurses giving an incorrect insulin dose.

Call for proposal

FP6-2002-IST-1
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH
Address
Leonhardstrasse 59
8010 Graz
Austria
Activity type
Research Organisations
EU contribution
€ 1 907 976

Participants (12)

TECHNISCHE UNIVERSITAET GRAZ
Austria
EU contribution
€ 421 905
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET GRAZ

Participation ended

Austria
EU contribution
€ 0
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 583 449
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
UNDEFINED

Participation ended

Belgium
EU contribution
€ 0
Address
Street, 1
Town
Activity type
Other
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 687 425
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
GAMBRO DIALYSATOREN GMBH
Germany
EU contribution
€ 385 802
Address
Holger-crafoord-strasse 26
72373 Hechingen
Activity type
Other
LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV
Germany
EU contribution
€ 528 017,40
Address
Bunsen Kirchhoff Strasse 11
44139 Dortmund
Activity type
Research Organisations
SENSLAB GESELLSCHAFT ZUR ENTWICKLUNG UND HERSTELLUNG BIOELEKTROCHEMISCHER SENSOREN MBH
Germany
EU contribution
€ 404 667
Address
Bautzner Str. 67
04347 Leipzig
Activity type
Other
B. BRAUN MELSUNGEN AG
Germany
EU contribution
€ 283 785
Address
Carl Braun Strasse 1
34212 Melsungen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 361 530
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
CARMEDA AB

Participation ended

Sweden
EU contribution
€ 12 000
Address
Kanalvagen 3B
194 61 Upplands Vasby
Activity type
Other
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 543 600
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments