Project description eHealthIntelligent glucose monitoringDevices to regulate the blood-sugar levels of critically ill patients in intensive care wards are set to improve treatment and even save lives when they go into commercial use in the coming years.Developed by the CLINICIP project, the intelligent devices address a potentially fatal side effect of trauma and shock: rapid increases in the body’s glucose levels that intensive care unit (ICU) doctors and nurses have typically found hard to control. As with diabetes, high glucose levels in trauma patients can be brought down through infusions of insulin. However, in an ICU environment the changes are often more rapid, and an excessive dose of insulin can lead to dangerously low blood sugar, a condition known as hypoglycaemia. Controlling the risks of irregular blood sugarThe CLINICIP team saw where technology could come to the aid of ICU patients. Working in collaboration with several European hospitals, they developed and tested a device to support nurses in deciding how much insulin and how frequently to administer it, while also working towards a more advanced system that would automate insulin injections entirely.The decision-support device, which is expected to be commercially available in 2009 after further trials, still relies on nurses drawing blood from patients and testing glucose levels in the traditional way. However, instead of administering the insulin directly they input the glucose information into the device via a touch screen. A specially designed algorithm then calculates how much insulin is needed before administering it to the patient. The device alerts nurses when blood samples need to be taken, which can be as frequently as every half hour.Using the system in trials, just one hypoglycaemic event was recorded in 434 ICU days.Automatic insulin injectionsThe automated version of the system, which the project partners expect to make available commercially in 2011, goes one step further in order to minimise the need for nurses to intervene. Using a glucose-monitoring interface and an insulin-infusion interface in a closed-loop system, the device draws blood samples from the patient automatically, calculates the insulin required to bring their blood sugar within normal levels, then administers the correct dose. Improving patients’ chances of survivalClinical trials in Europe have shown that such a device would probably dramatically improve the survival chances of critically ill patients who develop irregular glucose levels. Although hospitals frequently check blood sugar in ICU patients, few have implemented tight controls because of the risks of overcompensating and the need to have more nursing staff dedicated to glucose control.CLINICIP’s automated system overcomes both those problems, while its decision-support device reduces the risks of nurses giving an incorrect insulin dose. Show the project objective Hide the project objective Healthy people can develop atypical physiological symptoms under critically ill conditions, e.g. in the intensive care unit (ICU). Due to shock and trauma as a consequence of the surgery, the glucose concentration is likely to rise significantly comparable to the symptoms known as insulin-dependent Diabetes Mellitus. Similar to diabetes mellitus, the high glucose level needs to be treated with external insulin. According to a study in Belgium the intensive insulin therapy treatment cuts the mortality rates by 42% compared to standard insulin therapy for ICU indication.The project provides an intelligent system for improved health status monitoring of critically ill patients. A local system will be developed comprising biosensors for the determination of glucose in whole blood. Based on the continuous measurement, an adaptive control algorithm generates advice and thus represents a decision supporting system in an early project stage. Within a closed loop system intensified insulin treatment will make use of calculation results leading to the external regulation of glucose. In addition to the approach of controlling the glucose concentration, a minimally invasive treatment will be investigated. A number of biosensors for the determination of most important parameters such as lactate, carbon dioxide, oxygen and pH will be used to characterize adipose tissue.In order to support the implementation of intensified treatment in an optimal way, a telemedical infrastructure will be developed. This includes a knowledge sharing environment, allowing the involved clinical centres to store and share their newly generated knowledge. Additionally all data resulting from clinical trials will be saved on the server. In later stages of the project, access to the data and the derived clinical recommendations for treatment of critically ill patient will be granted to additional clinical partners who are willing to implement improved treatment. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorssocial sciencessociologydemographymortalitymedical and health sciencesclinical medicinesurgerymedical and health sciencesclinical medicinecritical care medicinemedical and health sciencesclinical medicineendocrinologydiabetes Programme(s) FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006). Topic(s) IST-2002-2.3.1.11 - eHealth Call for proposal FP6-2002-IST-1 See other projects for this call Funding Scheme IP - Integrated Project Coordinator JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH EU contribution € 1 907 976,00 Address LEONHARDSTRASSE 59 8010 Graz Austria See on map Region Südösterreich Steiermark Graz Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all TECHNISCHE UNIVERSITAET GRAZ Austria EU contribution € 421 905,00 Address RECHBAUERSTRASSE 12 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET GRAZ Participation ended Austria EU contribution € 0,00 Address UNIVERSITATSPLATZ 3 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 583 449,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNDEFINED Participation ended Belgium EU contribution € 0,00 Address Street, 1 Town See on map Activity type Other Links Contact the organisation Opens in new window Total cost No data UNIVERZITA KARLOVA Czechia EU contribution € 687 425,00 Address OVOCNY TRH 560/5 116 36 Praha 1 See on map Region Česko Praha Hlavní město Praha Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GAMBRO DIALYSATOREN GMBH Germany EU contribution € 385 802,00 Address HOLGER-CRAFOORD-STRASSE 26 72373 HECHINGEN See on map Activity type Other Links Contact the organisation Opens in new window Total cost No data LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV Germany EU contribution € 528 017,40 Address BUNSEN KIRCHHOFF STRASSE 11 44139 Dortmund See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SENSLAB GESELLSCHAFT ZUR ENTWICKLUNG UND HERSTELLUNG BIOELEKTROCHEMISCHER SENSOREN MBH Germany EU contribution € 404 667,00 Address BAUTZNER STR. 67 04347 LEIPZIG See on map Activity type Other Links Contact the organisation Opens in new window Total cost No data B. BRAUN MELSUNGEN AG Germany EU contribution € 283 785,00 Address CARL BRAUN STRASSE 1 34212 Melsungen See on map Region Hessen Kassel Schwalm-Eder-Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Total cost No data CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 361 530,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CARMEDA AB Participation ended Sweden EU contribution € 12 000,00 Address KANALVAGEN 3B 194 61 UPPLANDS VASBY See on map Activity type Other Links Contact the organisation Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 543 600,00 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data