Objective
The proposed project is based on a family of international patents and other intellectual property owned by one of the consortium partners (BioDevelops). The patents claim the use" of a natural protein with immunomodulatory activity as a diagnostic marker and as a drug candidate. The natural protein has been named "Progesterone Induced Blocking Factor" or PIBF. It has been shown by one of the consortium partners (Pro-Gestatione) that PIBF blocks the autoimmune response which normally leads to the killing of rapidly growing tissue, such as foetuses. High levels of PIBF are absolutely essential for the maintenance of normal pregnancy, therefore PIBF resembles a promising drug target. During the characterization of PIBF as an important mediator for the maintenance of pregnancy, it has surprisingly been shown that tumour cells also express PIBF, whereas no or low PIBF reactivity is found in the adjacent normal tissues. This indicates that PIBF constitutes an essential marker for tumour cells.
The proposal describes the required steps to develop a novel testing assay to diagnose malignant tumours, to monitor tumour therapy and to diagnose premature abortion risk. The development of this diagnostic method is based on Development of a validated Enzyme Linked Immuno Sorbent Assay (ELISA), Research concerning the expression of PIBF in malignant tumours, Research concerning the expression of PIBF during normal and risk pregnancy For future development of PIBF as a novel drug target to support in vitro fertilization therapy it is envisioned to capitalise on the experience of one of the consortium partners (Intercell), a vaccine specialist.
To achieve this goal it is required to Fully characterise PIBF via analytical testing in order to obtain GMP material for safety testing. The strategic objectives of this proposal are Development of a convenient testing assay to diagnose malignant tumours, to monitor tumour treatment in patients and to diagnose premature abortion...
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine obstetrics fetal medicine
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-SME-1
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SZEGED
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.