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Development of a technology to measure body fluid distribution in patients to improve dialysis treatment effieciency and patient comfort

Final Report Summary - HAEMOSCAN (Development of a Technology to measure body fluid distribution in patients to improve dialysis treatment efficiency and patient comfort)

The project aims at the solution of a clinically relevant problem. Up to now about 25 % of all dialysis patients suffer from acute complications (hemodynamic instability) during the treatment. Those instabilities are at least partly due to inadequate fluid balance as has been shown in several publications during the past 10 years. These instabilities provoke a tremendous discomfort to the patients suffering fainting, vomits and requiring relative long recovery periods. Apart from this discomfort, physiological problems affecting the patient's health are huge. It is needed to estimate with enough accuracy the fluid distribution in the patient during the dialysis treatment in order to take adequate countermeasures to avoid these instabilities. Up to date there are no suitable methods to measure on line this distribution with enough accuracy.

The HAEMOSCAN project proposed to use a non-invasive method that would allow to measure on line this fluid distribution. The use of such a technology would contribute towards improving the quality of life of the dialysis patients in Europe. Improvement of quality of life of persons that have to go through long weekly treatment periods and reduction of risk in this treatment is a very important result towards which this project is aiming.

At the time of writing this report tests have not been completed and only partial results have been evaluated. The preliminary conclusions of this analysis indicate a clear difference in the body shift behaviour (determined from the bioimpedance measurements with the HAEMOSCAN device) measured in the stable group of patients and in the unstable one. This analysis is to be completed with correlations between hypotension crises detected in the HD line pressure measurements taken over the unstable population and the direct bioimpedance measurements obtained with the sensor over the same population. Such correlation must confirm the ability of device in the early detection of the rise of hypotension crisis during HD.