Objective
The type l interferon receptor belongs to the class II cytokine receptor family and is expressed on all cell types as a heterodimeric complex that consists of the IFNAR1 and IFNAR2 subunits. Binding of interferon a/ß to its receptor triggers phosphorylation of associated tyrosine kinases of Jak family, Tyk2 and Jak1, and subsequent downstream signalling events. Recent findings have shown that Jak protein tyrosine kinases can control cellular responses to cytokines by influencing receptor localization, modulating their surface expression levels, and therefore the formation of functional high affinity receptors.
Based on initial studies with IFNAR1 and Tyk2, which revealed Tyk2 dependent IFNAR1 surface expression, I propose to study the role of Tyk2 in ligand dependent events. I will focus in particular on the potential role ofTyk2 in ligand-dependent IFNAR1 trafficking. A second aspect of the study will take into account IFNAR2 subunit of the type l interferon receptor and its associated tyrosine kinase Jak1. I propose to examine whether IFNAR2 surface expression is Jak1 dependent and to check whether and how does it correlate with expression of IFNAR1.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
PARIS
France
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