Objective
Cholesterol is an essential component of membrane lipid rafts and required for the development of neurons andglial cells in the central nervous system. The cellular source of cholesterol required for neurogenesis is unknown,but for synaptogenesis, a role o f astroglial cells has been hypothesized. To study the effect of cholesterolavailability during postnatal brain development in vivo, we have obtained a conditional mouse mutant that allowsinactivation of cholesterol biosynthesis in a cell-specific manner. Using the cre-lox system and two different Creexpressing lines, we will inactivate cholesterol synthesis in postmitotic cortical neurons and in postmigratorycerebellar granule cells. Neuronal differentiation and function will be assessed at early and late stages of braindevelopment using anatomical and histological techniques, behavior assays, as well as cell culture approaches.We hope that investigation of the basic cholesterol metabolism in the brain will help to understand the etiology ofdiseases linked to cholesterol metabolism, such as Alzheimer's disease or Smith-Lemli-Opitz syndrome.'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.