Objective
Recent progress on understanding of the genetic basis of human diseases has been catalysed by studies in model organisms. Transgenic mammalians, especially genetic knock-out mice have been proven as essential modelling tools for manifestation of human diseases, and further sophisticated models are necessary to continue the advancement.
In order to enhance our genetic understanding of human diseases, our recently established team in Hungary is planning to develop new transgenic laboratory animal models both in mo use and rabbit for comparative analyses of functional genomics indifferent species and for disease models. In the mouse gene-targeting technology has been possible thanks to stable embryonic stem cell lines.
In most mammalians the lack of such cell lines, however, has so far prevented targeted genetic modifications. This proposal is aimed to develop a technological platform for producing new transgenic models via new tools such as nuclear replacement and gene-targeting in somatic cells.
The project is aimed to significantly strengthen and provide a strong international element for a newly established research team in Hungary, and to conduct research primarily to further develop and validate the nuclear replacement system for safety and reliability as a technological platform.
Relevant issues, such as somatic cell gene targeting and standardisation of newly generated model animals by cryopreservation will be addressed. Our goal is also to generate the first gene targeted rabbit models for medical research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences medical biotechnology genetic engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine embryology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-8
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GODOLLO
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.