Objetivo The reasoning behind the HCTMCR project is the need to develop mild and regioselective synthetic routes for the preparation of heterocyclic compounds. Decorated heterocyclic scaffolds are very important as biologically active compounds in the drug discover y process. However, many traditional routes for the synthesis of heterocycles are not compatible with a variety of functional groups or substitution patterns. The work carried out within the HCTMCR research project is geared towards the discovery of new, i nnovative synthetic strategies that will overcome existing limitations and will make accessible a multitude of heterocyclic structures. One approach to achieving this goal will be the application of modern organometallic reactions, such as metal-catalyzed cross-coupling reactions or olefin metathesis. Thus, heterocycles such as substituted 1H- and 2H-indazoles, benzimidazoles, 2H-chromenes or quinolines will be accessible in a regioselective manner, as well as annulated heterocycles of various ring sizes. I n addition, microwave technology will be applied when necessary to optimize the respective reaction time and yield. Another aspect of the investigations performed within the HCTMCR project will be the use of readily available starting materials in a conver gent fashion. Thus, regioselective aromatic C-H bond activation or the activation of chlorine-substituted aromatic systems as one of the reaction partners will be studied. If applicable, the development of multi-component pathways will be pursued. Ámbito científico ingeniería y tecnologíaingeniería eléctrica, ingeniería electrónica, ingeniería de la informacióningeniería de la informacióntelecomunicaciónradiotecnologíatecnología de microondasciencias naturalesciencias químicasquímica orgánicacompuestos heterocíclicos Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-1.3 - Marie Curie Host Fellowships - Transfer of knowledge (TOK) Convocatoria de propuestas FP6-2002-MOBILITY-3 Consulte otros proyectos de esta convocatoria Régimen de financiación TOK - Marie Curie actions-Transfer of Knowledge Coordinador AVENTIS PHARMA DEUTSCHLAND GMBH Dirección Industriepark hoechst, building h821 Frankfurt am-main Alemania Ver en el mapa Aportación de la UE Sin datos
