Objective
Pharmacogenomics is an emerging discipline with a great potential for improving future clinical care. The linkage between the knowledge of treatment outcome and the underlying molecular alteration constitutes the principle of pharmacogenomics. The recent d evelopments of Herceptin (targeting the HER2 oncoprotein in breast cancer) and Glivec (targeting the BCR-ABL translocation in leukaemia) have demonstrated a close relationship between the molecular alteration and the clinical response. The success of these treatments has depended absolutely upon the development of appropriate clinical diagnostic tests (pharmacodiagnostics) to identify those patients, who are most likely to benefit from the treatment. The main objective of the proposed industry-academia part nership is to develop newpharmacodiagnostics to improve the selection of patients for targeted cancer therapies. DakoCytomation is a company at the forefront of the development of pharmacodiagnostics as evidenced by their strong involvement in ER and HER2. Dr. Bartlett research group at Glasgow University has achieved a unique expert position by combining translational research with histopathological evaluation of novel targeted cancer therapies tested by the pharmaceutical industry in European clinical tri als. Through exchange of experienced researchers, it is the intention to extend substantially the existing collaboration between DakoCytomation and Dr. Bartlett research group. This efficient way of combining complementary skills makes the objective very r ealistic. The new pharmacodiagnostic assays will be based on a) combining and optimising existing detection principles, b) combining detection of existing and/or novel markers on the same specimens and c) identifying new diseases/therapy indications for ex isting and optimised assays.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences clinical medicine oncology leukemia
- natural sciences biological sciences histology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-3
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GLOSTRUP
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.