Objective
The availability of in vitro models that mimic Absorption, Distribution, Metabolism, and Excretion (ADME) of new drugs in human combined with a thorough mechanistic knowledge about the processes that determine ADME, would greatly benefit the development of novel medicines. In many cases the hepatic uptake of drugs is mediated by Organic Anion Uptake Transporters (OATPs). Intracellularly, drugs are metabolized in two steps, termed phase I and phase II of drug metabolism which are catalysed by enzymes such as cytochromes P450 andUDP glucuronosyl- or suIfo-transferases respectively. The resulting conjugates are eliminated into the bile by drug efflux pumps.It is our objective to investigate the interaction of these various systems in vitro in recombinant cell l ines. The systems to be studied include human drug metabolizing enzymes (eg. sulfo-transferases and UDP-glucuronosyltransferases) and drug carriers (eg. Organic Anion Uptake Transporters (OATPs) and Multidrug Resistance Related Protein (MRP) efflux pumps). The project would be realized through a partnership between the Development Centre of Eli Lilly in Belgium and the University of Dundee. An experienced researcher would be hired by Lilly and would work for two years at Dundee where he would apply genomics for the characterization of cell line enzymes and molecular biology for the expression of human enzymes and carriers in those cell lines. During this period he would also spend some time at Lilly for the validation of the systems using specific probe subs trates. The researcher would benefit from the knowledge in genomics, proteomics, cell biology at Dundee and would transfer this knowledge at Lilly where he/she would return after two years, to implement therethese in vitro systems to screen new drugs and b etter predict their ADME characteristics. Researchers from Dundee would benefit from the experience of Lilly in analytical techniques used in ADME (e.g. mass spectrometry).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MONT SAINT GUILBERT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.