Objective
Malaria is responsible for more than 2 million deaths amongst children every year. As the mortality rate of 20-30% for severe falciparum malaria under even the best clinical conditions testifies, access to anti-malarial drugs is not sufficient to prevent an appreciable mortality from this disease. Understanding the cause of death at a cellular level is essential if additional rational treatments are to be developed. Most vaccine efforts are aimed at immunity against infection (antiparasitic) by targeting p arasite proteins. However, it has long been suggested that understanding the factors associated with resistance to severe clinical manifestations (anti-disease immunity) would lead to alternative approaches for malaria control. In these regard, parasite gl ycosylphosphatidylinositols (GPIs) appear to offer new opportunities. GPIs are a distinct class of glycolipids found ubiquitously in eukaryotic cells and implicated in several biological responses. GPIs are particularly abundant in parasites where they are found as free lipids and attached to proteins. In intraerythrocytic P. falciparum, GPIs represent the major glycoconjugates. P. falciparum GPIs have been identified as malaria pathogenicity factors based on their ability to induce inflammatory cytokines i n macrophages and cause symptoms reminiscentent of acute malaria infectionin experimental animals. We propose to determine the effect that Plasmodium GPIs have on this host mammalian cells and the importance of the GPIs role on the course of a malaria infe ction. We strongly believe this project will highly increases our possibilities of finding targets for pharmacological treatments of the disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- social sciences sociology demography mortality
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.