Objective
Biomedical devices increasingly rely on the use of silicon based microelectronic structures. During the NEUMIC project (IST-1999-29091) we successfully analyzed the parameters and mechanisms that control the degree of coupling between neurons and electronic devices and made significant progress towards the formation of chemical synapses. GOLDEN BRAIN aims at developing and implementing novel generic technologies to form reliable and durable bi-directional electrical and chemical communication between neurons and electronic devices. We will harness the basic properties of cells to identify, preferentially adhere and internalize elements of the extra cellular world by phagocytes, leading to the internalization of micro-nails that protrude from the transistor gate surface. Internalization provides 3 major advantages:
(1) Anchoring the cell to the transistor thus reducing its mobility;%:(2) Improved electrical coupling of neurons to the transistors;
(3) Improved sensing of neurotransmitters. The protruding u-nails are complemented by chemically modified surfaces decorating the various parts of the nail. Two cellular events are to be induced by the chemically modified surfaces:
(I) assembly of adherence junctions;
(II) internalization of the u-nails by membrane imagination. These will be achieved by:
(a) decorating the nails by biodegradable enzymes that facilitate degradation of the extra cellular matrix and allow intimate contact between the u-nail surface and receptors located on the external surface of the cell membrane;
(b) molecules that tether the cell membrane receptors and facilitate phagocytes or endocytosis of the m-nails by partial internalization;
(c) adhesion molecules that stabilize the binding of the cell membrane to the u-nails and their surroundings. This generic technology may serve as a basis for the construction of biomedical microstructures that will functionally link nerves to robotic prostheses and functionally link damaged neuronal networks.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry metalloids
- medical and health sciences medical biotechnology implants
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.