Objective
The proposal presented here represents a continuation of the work I have done in the USA on
T lymphocyte peripheral tolerance and autoimmune diabetes. My goal is to gain a better
understanding of the disregulation of the mechanisms of immune tolerance leading to the activation of
autoreactive T cells in autoimmune processes. This will allow us to rationally design new therapeutic
strategies against type 1 diabetes in particular that can prevent or stop the progression of the disease
before insulin function is lost. These forms of therapy are inexistent at the present time.
The interplay among three types of cells plays an important role in the onset of type 1 diabetes.
These are CD8+ T cells, CD4+ T helper cells and antigen presenting cells (APCs). In a normal
situation, tolerogenic APCs will pick and transport self-antigens from the parenchyma to the draining
lymph nodes where they will silence CD8+ and CD4+ T cells. If CD4+ T cell tolerance fails, CD4+
helper cells will activate APCs that in turn will promote the differentiation of potentially autoreactive
CD8+ T cells into diabetogenic killer cells. Based on this hypothesis, the aim of this project is to
decipher the cellular and molecular interactions responsible for the establishment of T cell tolerance to
pancreatic antigens and the activation of potentially autoreactive T cells leading to autoimmunity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.