Objective
The present proposal has as main and general objective the study of the functional properties of peptides existing in dry-cured ham in relation with their ability to reduce blood pressure, with the aim to evaluate if dry-cured ham intake, despite its NaCl content, can be recommended for hypertensive population. The effect due to the presence of certain peptides having hypotensive properties could balance this NaCl content, or even give a net hypotensive effect due to ham intake. The results of the present s tudy could help in the regulation of blood pressure through diet, with the positive consequences that, especially for the hypertensive population, this would imply. This goal will be achieved by the transfer of knowledge and skills that the applicant, Dr. Sentandreu, has acquired during his initial Marie Curie Fellowship working in Dr. Ouali's laboratory at INRA of Theix (France). The present proposal will benefit from this important scientific background by the implementation of two concrete objectives: A. - Isolation and identification of peptides. naturally present in dry-cured ham, having a remarkable antihypertensive activity: By use of Chromatographie techniques, we will isolate the peptides contained in a dry-cured ham peptide fraction selected for hav ing remarkable antihypertensive activity. For each one of the separated peptides, their hypotensive activity will be tested in vitro. Furthermore, for those peptides having the highest antihypertensive activity their sequence will be elucidated by use of p roteomic techniques. B.- Development of immunological methods for the direct quantification of key antihypertensive peptides in ham extracts: Peptides showing the best antihypertensive properties will become key markers to evaluate, in the future, the pote ntial role of the different types and qualities of dry-cured ham in the regulation of blood pressure. To accomplish a precise, specific, rapid and easy quantification of #
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences health sciences nutrition
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.