Objective
Recent findings point to a relevant role of epigenetic phenomena in developmental issues in animals and plants. Epigenetics has been described to affect cancer, fate programming and developmental transitions. In the vegetal kingdom it has been related to e mbryo development, floral transition, vernalization and transgene silencing. The analysis of two independent insertional mutants in a SWI3-like gene, in the model plant Arabidopsis thaliana, suggests that the Swi/Snf complexes are involved in regulation of transcriptional silencing of genes affecting gamete formation and embryo development. The morphological characterization of such a defect and the link to silencing will reveal a new element in the epigenetic mechanisms, and will establish new tools for ga mete and embryo development studies. It is hypothesized that the disruption of the SWI3-like gene originates the epigenetic modification of a second gene, causing alterations in the gamete formation. Positional mapping of this gene would prove the current hypothesis and would reveal a key element in gamete development. The proposed research activity is also taking into account the mutational analysis of other components of the putative Swi/Snf complex in Arabidopsis. Different T-DNA collections will be sear ched for mutants in such a genes, and the effect of these mutations will be described. Finally, plants expressing Swi3-like and Bsh (Snf5-like) proteins fused to an epitope will allow the tracking of these proteins, and the purification and co-immunoprecip itation of Arabidopsis Swi/Snf complexes. The final aim of this proposal is the combination of exciting research topics as chromatin remodeling and epigenetics with a rising model organism with a recently sequenced genome as Arabidopsis thaliana.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences genetics epigenetics
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VALENCIA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.