Objective
Current theoretical approaches to schizophrenia invoke dysfunction in fronto-striatal circuits. The proposed study aims to provide a direct test the fronto-striatal hypothesis, by examining whether, in chronic schizophrenic patients, executive test impairm ent and task-related prefrontal cortex abnormality on functional imaging are associated with motor disorder, including both tardive dyskinesia and catatonic symptoms. In the context of working on a severe mental disorder unit over a period of 12 months, 15 0 non-elderly patients meeting criteria for chronic schizophrenia will undergo a standardised examination procedure for motor disorder. From these, three groups with relatively intact overall intellectual functioning, will then be selected: those with moto r disorder (predominantly tardive dyskinesia) (N-25), those with motor disorder (predominantly catatonia) (N=20) and those with no motor disorder (N=25). A group of 25 healthy comparison subjects will also be recruited. Executive function will be examined in order to examine the hypothesis that motor abnormality is specifically associated with executive impairment. Event related fMRI experiments will be carried out on 12 subjects from each group .using a range of tasks that activate frontal brain systems. A s well as adding to knowledge about the biological basis of schizophrenia, if frontal/executive dysfunction is shown to be a risk factor for tardive dyskinesia in schizophrenia, this could be of potential practical clinical usefulness as a screening test f or this serious side-effect of drug treatment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.