Objective
Alzheimer's disease (AD) is the most common neurodegenerative disease. The unmet needs (medical, social and economic) in AD are enormous. This proposal focuses on the development to the preclinical stage of novel chemical entities endowed with specific neuro-protective activity in AD and capitalizes on the most widely accepted view on the etiology of AD. A validated in vitro model of A? neuro-toxicity, established tran-scriptomics and proteomics methodologies and sophisticated bio-informatics tools are used in order to identify proteins causally involved in A?-mediate neuro-degeneration. An efficient drug discovery pipeline, including stringent target validation based on in vitro, in vivo and ex vivo approaches, will be employed to bring two drug candidates to the clinic.
The differentiators in this proposal lie in the target identification part of the project and in the capacity to materialize fundamental insights of mechanisms of action into drug candidates for clinical testing, and can be summarized as a) the strategy (emphasis on the early, initial response of the neuronal culture to A?; b) the approach (emphasis on the analysis of differential protein phosphorylation in order to identify signal transduction components and on DNA microarray analysis in order to identify the first wave of transcriptional response); c) the analysis, (bioinformatics is employed to merge Proteomics and Transcriptomics data into a coherent view of A?-mediated signal transduction in neurons to generate"pathopathways"); d) the drug discovery expertise to convert knowledge into potential therapies. The partners in this integrated project have been selected for their specific competencies in the different contribution areas, and the presence of an SME as project coordinator will ensure a milestone-driven progression of the project and the translation of scientific findings into the reality of drug discovery.'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences genetics DNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SIENA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.