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Multi-organismic approach to study normal and aberrant muscle development, function and repair

Objective

In Europe over 300.000 people are affected by muscular dystrophies whilst the majority of the aged population are affected by muscle degeneration leading to decreased mobility and loss of independence. This has severe consequences at both a personal and ec onomic level. The aim of this proposal is to understand how these muscular defects can be repaired. Thus, the proposed project will restructure European research and will: i) integrate internationally recognised European specialists working on various aspe cts of muscle biology and pathology in a number of model organisms; ii) federate their research on well defined aims and obtain a critical mass of researchers who will be able to make significant scientific advancements; iii) create state-of-the-art techni cal platforms and resources which will serve the network's scientific aims; iv) organize the rapid transfer and application of knowledge acquired in genetically amenable organisms into specific applications for human muscle diseases; v) broadly publicize o ur scientific action and, through education, attract younger generation of scientists into this essential field of research. All aspects of muscle differentiation are to be investigated and this will be translated into the mechanisms of repair in the adult . Fundamental to the advancement of our knowledge is the recent demonstration that, throughout evolution, many of the molecular mechanisms regulating muscle differentiation have been highly conserved. As molecular pathways can be easily assessed in inverte brates, we will exploit this advantage and rapidly extend the knowledge gained in these systems to determine gene function in higher vertebrates. This is a unique aspect of the proposal and places the consortium at the international forefront of understand ing of gene function during normal muscle development and disease.'

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

NoE - Network of Excellence

Coordinator

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
EU contribution
No data
Address
101, rue de Tolbiac
PARIS
France

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
No data

Participants (33)

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Last update: 5 July 2010

My Booklet

Permalink: https://cordis.europa.eu/project/id/511978

European Union, 2026

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