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Multi-organismic approach to study normal and aberrant muscle development, function and repair

Objective

In Europe over 300.000 people are affected by muscular dystrophies whilst the majority of the aged population are affected by muscle degeneration leading to decreased mobility and loss of independence. This has severe consequences at both a personal and ec onomic level. The aim of this proposal is to understand how these muscular defects can be repaired. Thus, the proposed project will restructure European research and will: i) integrate internationally recognised European specialists working on various aspe cts of muscle biology and pathology in a number of model organisms; ii) federate their research on well defined aims and obtain a critical mass of researchers who will be able to make significant scientific advancements; iii) create state-of-the-art techni cal platforms and resources which will serve the network's scientific aims; iv) organize the rapid transfer and application of knowledge acquired in genetically amenable organisms into specific applications for human muscle diseases; v) broadly publicize o ur scientific action and, through education, attract younger generation of scientists into this essential field of research. All aspects of muscle differentiation are to be investigated and this will be translated into the mechanisms of repair in the adult . Fundamental to the advancement of our knowledge is the recent demonstration that, throughout evolution, many of the molecular mechanisms regulating muscle differentiation have been highly conserved. As molecular pathways can be easily assessed in inverte brates, we will exploit this advantage and rapidly extend the knowledge gained in these systems to determine gene function in higher vertebrates. This is a unique aspect of the proposal and places the consortium at the international forefront of understand ing of gene function during normal muscle development and disease.'

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Coordinator

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
Address
101, Rue De Tolbiac
Paris
France

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Participants (33)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel-ange
Paris

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THE UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Firth Court, Western Bank
Sheffield

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KING'S COLLEGE LONDON
United Kingdom
Address
The Strand
London

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UNIVERSITY OF EAST ANGLIA
United Kingdom
Address
Earlham Road
Norwich

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UNIVERSITY OF WALES, CARDIFF
United Kingdom
Address
7th Floor, 30-36 Newport Road
Cardiff

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PASTEUR INSTITUTE
France
Address
25-28 Rue Du Dr.roux
Paris

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EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg

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TECHNICAL UNIVERSITY BRAUNSCHWEIG
Germany
Address
Pockelsstrasse. 14
Braunschweig

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INSTITUTE OF PHYSIOLOGY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
Prague

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PHILIPPS-UNIVERSITÄT MARBURG
Germany
Address
Biegenstrasse 10
Marburg

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CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Serrano 116
Madrid

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THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Address
The Authority For Research And Development, Edmond J.safra Campus, Givat Ram
Jerusalem

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IMPERIAL COLLEGE LONDON
United Kingdom
Address

London

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THE UNIVERSITY OF YORK
United Kingdom
Address
Heslington
York

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THE INSTITUTE OF CANCER RESEARCH : ROYAL CANCER HOSPITAL
United Kingdom
Address
123 Old Brompton Road
London

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INSERM TRANSFERT SA
France
Address
101 Rue De Tolbiac
Paris

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SOLUSCIENCE SA
France
Address
Biopole Clermont-limagne
Saint-beauzire

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THE VICTOR CHANG CARDIAC RESEARCH INSTITUTE
Australia
Address
Level 6, 384 Victoria Street
Darlinghurst

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UNIVERSITY OF BRISTOL
United Kingdom
Address
Senate House, Tyndall Avenue
Bristol

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CENIX BIOSCIENCE GMBH
Germany
Address
Tatzberg 47
Dresden

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Links
UNIVERSITY OF VIRGINIA
United States
Address
1001 North Emmet Street
Charlottesville

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MONASH UNIVERSITY
Australia
Address
Wellington Road
Clayton, Victoria

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GENOWAY S.A.
France
Address
181 Avenue Jean Jaures
Lyon

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BITPLANE AG
Switzerland
Address
Badenerstrasse 682
Zurich

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COLLGARD BIOPHARMACEUTICALS LTD
Israel
Address
Hamanofim 11
Herzliya

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ASSOCIATION FRANÇAISE CONTRE LES MYOPATHIES
France
Address
1 Rue De L'internationale - Bp59
Evry

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INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE - GROUPEMENT D'INTÉRÊT ECONOMIQUE
France
Address
1, Rue Laurent Fries
Illkirch

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MAX PLANCK SOCIETY REPRESENTED BY MAX-PLANCK-INSTITUTE FOR PHYSIOLOGICAL AND CLINICAL RESEARCH (W. G. KERCKHOFF INSTITUTE)
Germany
Address
Parkstrasse 1
Bad Nauheim

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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
Germany
Address
Robert-rössle Strasse 10
Berlin

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Royal Holloway and Bedford New College
United Kingdom
Address
Egham Hill
TW20 0EX Egham

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UNIVERSITÀ DEGLI STUDI DI PADOVA
Italy
Address
Via Vii Febbraio 2
Padova

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UNIVERSITÄTKLINIKUM FREIBURG
Germany
Address
Hugstetter Strasse 49
Freiburg

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UNIVERSITÉ PIERRE ET MARIE CURIE
France
Address
Place Jussieu, 4
Paris

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