Objective Heart failure caused by the ischaemic heart disease is one of the most common causes of morbidity an mortality across Europe, especially high among elderly people, but the post-infarction myocardial injury is also major cause of disability in younger survi vors from myocardial infarction. The proposed project is dedicated to stimulate "state-of-the-art" research on the clinical applications of autologous stem cells, including bone marrow derived stem cells as well as myoblasts, to the regeneration of heart m uscle in irreversibly damaged post- infarction regions. The consortium includes most experienced European clinical researchers in the field, which already had accomplished the phase I clinical trials in participating centres. The researchers from participa ting centres have agreed to coordinate their future clinical trials on stem cell transplantation for myocardial regeneration in patients with postinfarction heart failure, as a result of the proposed project. This will include analysis of polled clinical d ata obtained in participating centres, reciprocal exchange of information on cell culture and cell preparation for transplantation. This will also include standardization of clinical protocols aiming at evaluation of the clinical efficacy of myocardial rep lacement therapy as well as hand-on training of different techniques of cell delivery, including percutaneous cell transplantations, in particular trans-coronary arteries bone marrow stem cell delivery protocols as well as trans- ventricular and trans-card iac-veins myoblast injection techniques. As a result of further integration of the consortium, it is expected to stimulate formation of a common future phase III studies at international level, especially with an option of submitting future Integrated Proj ect application within the 6th Framework Programme. Fields of science social sciencessociologydemographymortalitymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinecardiologymedical and health sciencesclinical medicinetransplantation Keywords Stem cells cell therapy organ regeneration Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-2.1.0-2 - Coordination of clinical trials in Europe LSH-2003-3-3 - Promotion of cooperation with Associated Candidate Countries Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme SSA - Specific Support Action Coordinator UNIVERSITY SCHOOL OF MEDICAL SCIENCES Address Ui. fredry 10 Poznan Poland See on map Links Website Opens in new window EU contribution € 0,00 Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all HOPITAL EUROPEEN GEORGES POMPIDOU France EU contribution € 0,00 Address 20, rue leblanc Paris See on map UNIVERSITY OF VALLADOLLID Spain EU contribution € 0,00 Address Ramon y cajal 3 Valladolid See on map UNIVERSITY OF ROSTOCK Germany EU contribution € 0,00 Address Schilligallee 35 Rostock See on map Links Website Opens in new window CHARLES UNIVERSITY PRAGUE Czechia EU contribution € 0,00 Address Ruska 87 Prague See on map Links Website Opens in new window UNIVERSITY HOSPITAL, CLERMONT-FERRAND France EU contribution € 0,00 Address Rue montalembert Clermont-ferrand See on map VILNIUS UNIVERSITY Lithuania EU contribution € 0,00 Address Santariskiu str. 2 Vilnius See on map Links Website Opens in new window POLISH ACADEMY OF SCIENCES Poland EU contribution € 0,00 Address Strzeszynska 32 Poznan See on map Links Website Opens in new window ERASMUS UNIVERSITY ROTTERDAM Netherlands EU contribution € 0,00 Address Drmolewaterplein 40 Rotterdam See on map Links Website Opens in new window
