Objective
This EURExpress integrated project responds to the priority topic "Global in site gene expressions analysis in rodent models and human tissues". EURExpress integrates European skills, efforts, resources and information in the field of systematic gene expression analysis. Expression data of > 20,000 genes will be generated by RNA in site hybridisation (ISH) on E14.5 wild type marine embryos which will result in detailed description (at a cellular level) of gene expression patterns. A "transcriptome atlas" will be generated using a newly developed automated RNA ISH system. Automated scanning microscopes will collect image data which will be electronically sent out in a digital format for annotation. The latter will be performed using a web-based "virtual" microscope and entered in a hierarchical database designed to hold large amounts of image data and display them in a user-friendly format. For a subset of genes, mainly those directly involved in human diseases, expression data will also be generated by using human and murine tissue arrays. This will offer the opportunity to compare human and mouse expression patterns in adult tissues. This project builds a strong European concentration of skills in gene expression analysis and mouse geneomics. It will allow integration with existing European Projects, such as mouse mutagenesis and mouse phenotyping projects, which critically depend on detailed information on gene expression patterns. Integration of the efforts of several European laboratories will result in the standardization of methods to generate, collect and display gene expression data. Furthermore, technological expertise will be disseminated by training and exchange programs. All expression data will be made readily available to the scientific community via the EURExpress web-linked database, advancing our knowledge of gene function and having a significant impact on the identification of gene expression markers of disease processes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROME
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.