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Advances in hearing science : from functional genomics to therapies

Objective

EuroHear has two closely inter-related objectives.These are (1 )to provide fundamental knowledge about the development and function of the inner ear,and (2) to identify the molecular defects underlying hereditary hearing impairments (HI), including presbycusis,one of the most frequent forms of HI.Achieving these objectives will facilitate the development of therapies for alleviating HI.In order to address the above issues, the EuroHear project is organised into 4 components: 1-The identification of genes underlying sensorineural HI in humans and mice. 2-The analysis of the molecular and cellular mechanisms underlying the development and function of: "The hair bundle "The ribbon synapses of the hair cell and outer hair cell electromotility. "The ion channels, ion transporters and gap junction channels that contribute to the potassium homeostasis. 3-The standardisation, implementation and development of technologies. 4-The development of new tools for preventing and curing HI. Currently, we identify a multidisciplinary approach as the sina qua non condition for further progress in understanding the inner ear.The EuroHear consortium comprises a group of laboratories that are world experts in a variety of hearing research fields.EuroHear is a continuation and extension of a previous European consortium that has successively tackled early-onset,Mendelian forms of deafness and hearing loss.The success of this European consortium,which has identified half of the 37 known genes for isolated forms of HI in humans,has been due in large part to intense collaboration between human and mouse geneticists.Expected contributions of EuroHear include a standardisation of investigative protocols, the provision of access to large-scale platforms for genetics and genomic analysis,the development and diffusion of physiological and biophysical techniques of relevance for functional investigations of the inner ear,the creation of a variety of mouse

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Coordinator

INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac
Paris
France

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Participants (28)

UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London

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TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
39040 Tel Aviv

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MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
n/a London

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STICHTING KATHOLIEKE UNIVERSITEIT, UNIVERSITY MEDICAL CENTRE NIJMEGEN
Netherlands
Address
Geert Grooteplein 10
Nijmegen

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UNIVERSITATSKLINIKUM FREIBURG
Germany
Address
Hugstetter Strasse 49
Freiburg

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MAX PLANCK SOCIETY FOR THE ADVANCEMENT OF SCIENCE, REPRESENTED BY THE MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS
Germany
Address
Pfotenhauerstr. 108
Dresden

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ZENTRUM FUR MOLEKULARE NEUROBIOLOGIE, UNIVERSITAT HAMBURG
Germany
Address
Martinistrasse 52
Hamburg

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UNIVERSITY OF SUSSEX
United Kingdom
Address
Sussex House
Falmer, Brighton

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UNIVERSITATSKLINIKUM BONN
Germany
Address
Sigmund-freud-strasse 25
Bonn

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COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Batiment Le Ponant D - 25 Rue Le Blanc
Paris

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ISTITUTO VENETO DI MEDICINA MOLECOLARE - CENTRO DI RICERCA DELLA FONDAZIONE PER LA RICERCA BIOMEDICAL
Italy
Address
Via G. Orus 2
Padova

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FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL
Spain
Address
Carretera De Colmenar, Km 9
Madrid

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UNIVERSITATSMEDIZIN GOTTINGEN - GEORG-AUGUST-UNIVERSITAT GOTTINGEN - STIFTUNG OFFENTLICHEN RECHTS
Germany
Address
Robert-koch-str. 40
Goettingen

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UNIVERSITY OF HELSINKI - HELSINGIN YLIOPISTO
Finland
Address
Yliopistonkatu 4
Helsingin Yliopisto

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LNSTITUT CURIE, DIVISION DE RECHERCHE
France
Address
26, Rue D'ulm'
Paris

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GENOME RESEARCH LIMITED
United Kingdom
Address
183 Euston Road
London

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KAROLINSKA INSTITUTET
Sweden
Address
Nobels Vag 5
Stockholm

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UNIVERSITEIT ANTWERPEN
Belgium
Address
Prinsstraat 13
Antwerpen

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INSTITUTE OF EXPERIMENTAL MEDICINE, HUNGARIAN ACADEMY OF SCIENCES
Hungary
Address
Szigony U. 43.
Budapest

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ACREO AB
Sweden
Address
Electrum 236, Lsafjordsgatan 22
Kista / Stockholm

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INTEGRAGEN SA
France
Address
4, Rue Pierre Fontaine
Evry

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AFFICHEM
France
Address
10, Avenue De L'europe'
Ramonville-saint-agne

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INSERM TRANSFERT SA
France
Address
7 Rue Watt
Paris

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UNIVERSITY OF SFAX FOR THE SOUTH
Tunisia
Address
Rte De L'aeroport Km 0.5'
Sfax

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INSTITUTE OF GENETICS UNIVERSITY OF BONN
Germany
Address
Roemerstrasse 164
Bonn

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UNIVERSITY HOSPITAL OF THE UNIVERSITY OF COLOGNE
Germany
Address
Kerpener Str. 62
Cologne - Koln

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MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN
Germany
Address
Robert-rossle-str. 10,
Berlin

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PHILIPPS-UNIVERSITAT MARBURG
Germany
Address
Biegenstrasse 10
Marburg

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