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Content archived on 2024-05-29

Advances in hearing science : from functional genomics to therapies

Objective

EuroHear has two closely inter-related objectives.These are (1 )to provide fundamental knowledge about the development and function of the inner ear,and (2) to identify the molecular defects underlying hereditary hearing impairments (HI), including presbycusis,one of the most frequent forms of HI.Achieving these objectives will facilitate the development of therapies for alleviating HI.In order to address the above issues, the EuroHear project is organised into 4 components: 1-The identification of genes underlying sensorineural HI in humans and mice. 2-The analysis of the molecular and cellular mechanisms underlying the development and function of: "The hair bundle "The ribbon synapses of the hair cell and outer hair cell electromotility. "The ion channels, ion transporters and gap junction channels that contribute to the potassium homeostasis. 3-The standardisation, implementation and development of technologies. 4-The development of new tools for preventing and curing HI. Currently, we identify a multidisciplinary approach as the sina qua non condition for further progress in understanding the inner ear.The EuroHear consortium comprises a group of laboratories that are world experts in a variety of hearing research fields.EuroHear is a continuation and extension of a previous European consortium that has successively tackled early-onset,Mendelian forms of deafness and hearing loss.The success of this European consortium,which has identified half of the 37 known genes for isolated forms of HI in humans,has been due in large part to intense collaboration between human and mouse geneticists.Expected contributions of EuroHear include a standardisation of investigative protocols, the provision of access to large-scale platforms for genetics and genomic analysis,the development and diffusion of physiological and biophysical techniques of relevance for functional investigations of the inner ear,the creation of a variety of mouse

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

IP - Integrated Project

Coordinator

INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE
EU contribution
No data
Address
Rue de Tolbiac
PARIS
France

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (28)

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