Objective
Elucidation of the function of the 25.000 genes in the human genome will he significantly accelerated by exploiting comparative genomic approaches in an integrative manner. The international community has or will soon have access to the complete genome seq uence of' several organisms, already validated as excellent experimental models of developmental biology. It is essential that European scientists rapidly co-ordinate an efficient interfacing in their strengths in comparative bioinformatics and functional genomic approaches. This synergy towards comparative functional gcnomics will be an inescapable component in the process of exploiting and dissecting gene regulation and function of human development and disease. Comparisons across several vertebrate and i nvertebrate systems allow us by bioinformatics analysis to rapidly identify thousands ofsequenced- conserved orthologous genes. The rationale is that orthologous genes with important biological roles will most likely have conserved functions in mammals, in cluding humans. The aim of the proposal is to organise the coordination of the research of several recognised European laboratories using the amphibian Xenopus as a model to identify vertebrate genes of medical and developmental interest. The ease of study ing gene expression and function in vivo in this model will facilitate the identification of conserved functions. To fulfil these goals, the consortium will increase the collaboration between these labs und coordinate the "vertical" studies from m silico d efinition of orthologous genes (comparisons across all available genomic models) down to gene expression and function studies. Analyses of many genes by high throughput techniques will be followed by in depth analysis of gene sets selected for their import ance in human health. Another side-product of our action is the dissemination of the improvements of biotechnological techniques made by some of us for modulating gene function in Xenopus.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences other social sciences development studies social developments
- natural sciences biological sciences developmental biology
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.