Skip to main content
Aller à la page d’accueil de la Commission européenne (s’ouvre dans une nouvelle fenêtre)
français français
CORDIS - Résultats de la recherche de l’UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Contenu archivé le 2024-05-29

Reprogramming the immune System for the Establishment of Tolerance

Objectif

Transplantation dramatically improves the survival of patients with end-stage failure of vital organs. However, as a directconsequence of the immunosuppressive drugs permanently required to prevent rejection, recipients have a significantly increased risk of infection and malignancies. Moreover, these drugs are expensive, do not prevent long-term damage of the graft, and exert toxic effects outside the immune system. The induction of transplant tolerance, defined as permanent acceptance of the graft in absence of continuous immunosuppression, would be a major step forward. Recent advances in post-genomic immunology suggest that this goal is achievable in a near future. Indeed, new biotechnology products have been shown to promote long-term transplant acceptance in pre-clinical models. RISET will focus on the translation of these advances into industrial development and clinical practice. First, diagnostic tests to identify transplanted patients for whom immunosuppressive treatment could be safely minimized or withdrawn will be developed. These tests will be applied to patients under conventional treatment as well as to patients enrolled in pilot clinical investigations based on cellular products with potential for tolerance induction. Because of the nature of this research, effective communication with patient organizations and regulatory bodies will be organized, and related ethical and societal questions will be specifically addressed. In parallel, relevant models of tolerance will be used to identify new genes, molecules or cell types that will form the basis for novel diagnostics and therapeutic approaches. The exploitation of the knowledge created in RISET will be facilitated by the building of an industrial platform. In order to exploit innovative concepts emerging outside the consortium, RISET will be open to new industrial or academic partners for which a budget has been provisioned. An external advisory board will monitor the progress.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

Vous devez vous identifier ou vous inscrire pour utiliser cette fonction

Mots‑clés

Programme(s)

Thème(s)

Appel à propositions

FP6-2003-LIFESCIHEALTH-I
Voir d’autres projets de cet appel

Régime de financement

IP - Integrated Project

Coordinateur

UNIVERSITE LIBRE DE BRUXELLES
Contribution de l’UE
Aucune donnée
Adresse
AVENUE FRANKLIN ROOSEVELT 50
BRUXELLES
Belgique

Voir sur la carte
Liens
Coût total
Aucune donnée

Participants (25)

Partager cette page Partager cette page sur les réseaux sociaux

Télécharger Télécharger le contenu de la page

Dernière mise à jour: 12 Octobre 2010

Mon livret

Permalink: https://cordis.europa.eu/project/id/512090/fr

European Union, 2025