Objective
This integrated project focuses on unravelling mechanisms of DNA damage response and repair, an area with a major impact on human health, notably cancer, immunodeficiency, other ageing related-diseases and inborn disorders. The proposal brings together le ading groups with multi-disciplinary and complementary expertise to cover all pathways impinging upon genome stability, ranging from molecules to mouse models and human disease. Objectives: The main objective is to obtain an integrated perception of the in dividual mechanisms, their complex interplay and biological impact, using approaches ranging from structural biology to systems biology. Translation of the results that we obtain is expected to contribute to an improved quality of life through (1) possible identification of genetic markers for assessment of susceptibility to occupational hazards and disease, (2) discovery of promising targets for therapy, (3) improved diagnostic and prognostic procedures for genetic disorders, (4) early diagnosis and preven tion of cancer and other ageing-related diseases. We have also included a strong training component in the project to invest in young talented students, who may become the leaders of tomorrow. Approach: The pleiotropic effects inherent to the time-dependen t erosion of the genome and the complexity of the cellular responses to DNA damage necessitate a comprehensive, multi-disciplinary approach, which ranges from molecule to patient. At the level of structural biology and biochemistry, individual components a nd pathways will be analysed to identify new components and clarify reaction mechanisms. The interplay between pathways and cross-talk with other cellular processes will be explored using both biochemical and cellular assays. To better understand the funct ion and impact of DNA damage response and repair systems in living organisms, we will take full advantage of our existing unique and extensive collection of models #
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROTTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.