Objective
We will demonstrate the power of a Systems Biology approach to study the regulatory network structure of the most fundamental biological process in eukaryotes: the cell cycle. An integrative approach will be applied to build a basic model of the cell cycle, in four different species including S. cervisiae (budding yeast), S. pombe (fission yeast), A. thaliana (weed, model plant) and human cells. To do this,a Consortium is assembled of leaders in the fields of cell cycle biology, functional genomics technologies, database design and development, data analysis and integration technology, in addition to modelling and simulation approaches. The project combines a number of complementary data sets, toward an advanced mining and modelling environment designed to assist the biologist in building and amending hypotheses, and to help the investigator when designing new experiments to challenge these hypotheses. By doing this simultaneously in widely different organisms we will ensure that the tools are generally applicable across species. By bringing together in the design phase biologists, bioinfomaticians, biomathematicians and (commercial) software developers we will ensure that a user-friendly, intuitive data analysis environment is created.The main data streams generated de novo within the project concern transcript profiling and proteomics data (Y2H and TAP).These data will be complemented with information extracted through comparative genomics, and prior knowledge coming from literature mining (text mining toots). The project will bring together a number of existing technologies to build a knowledge warehouse in a relational database designed to contain cell cycle regulatory network information, accessible through an intuitive user platform (GUI) with embedded modelling tools.This platform will enable both top-down and bottom- up hypothesis-driven research, and it will serve as a basis to develop more rigorous dynamical models.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences computer and information sciences data science data mining
- natural sciences computer and information sciences software software applications simulation software
- natural sciences computer and information sciences databases relational databases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.