Objective
GenOSept is a specific targeted research project (STREP) which uses a multidisciplinary fundamental genomics approach (gene expression, structural genomics, population genetics) to examine genetic predisposition to sepsis. Sepsis (life-threatening infection) is a major public health problem throughout Europe. In the USA in 1995 it cost $17 billion to treat 751,000 patients with severe sepsis, of whom 28.6% died. The Center for Disease Control suggests that sepsis-attributable mortality rates are rising. We hypothesize that susceptibility to expensive new treatments, and fatal outcomes from severe sepsis, are in part, genetically determined. GenOSept work packages will test this hypothesis using the following approach. We will use gene expression studies to define novel candidate genes including those controlling programmed cell death. The novel candidate genes so identified will then be analysed in subsequent epidemiologic studies of genetic predisposition to sepsis-related mortality and morbidity in European intensive care units. The European Society of Intensive Care Medicine (ESICM) will co-ordinate a consortium of leading experts in sepsis, genomics, genetic epidemiology, biometrics and genetic high-throughput genotyping to link this new science to patient-centred outcomes. GenOSept will provide important data on gender-related mortality and morbidity. It will have a major impact on diagnosis and treatment of European sepsis patients in subsequent therapeutic trials by targeting risk subpopulations and focussing expensive new treatments. GenOSept will standardise protocols for genotyping, facilitate application of new knowledge in functional and structural genomics, harmonize high-throughput genotyping and quality control between major European centres, and contribute to reducing sepsis-related mortality in European health care.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences health sciences public health epidemiology
- medical and health sciences clinical medicine critical care medicine
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BRUSSELS
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.