Objective
After decoding the genomes of several living organisms, the main interest of biologists is focused on protein studies. This new field of biology -the proteomics- is signified by large-scale protein analysis and needs high-throughput approaches. Progress of the proteomics studies are largely depends on availability of sufficient amount of a large number of proteins. Presently, the protein production is cumbersome and has to be optimised on case-by-case basis. We aim at delivering solution for this bottleneck of proteomics by devising a 'protein factory'. Elimination this rate-limiting step speeds up the proteomics research. We exploit the 'protein factory' in two applications, first, to devise a general substrate hunting protocol; second to invent protein-detecting micro-arrays (PDM). Identification of protein kinase substrates is a major challenge of the post-genomic era and requires improved methodologies. Despite several efforts with different methods the identification has been slow and intricate.
We describe a feasible protocol suitable for high-throughput substrate screening in any organism. We use this protocol for identification of plant kinase substrates involved in pathogen responses; hence, the expected results help understanding this agriculturally important process. PDMs are the protein sensors of future and could be used -besides basic science- in human diagnostic, food industry and environmental sciences. Development of these chips requires ample amount of assorted proteins, which could be conveniently produced with our system.
During my training, I participated in European and national projects and established essential connections. The complexity of research objectives needs dedicated experts from a number of field therefore urge cross-border and national co-operations. I can transfer my acquired knowledge to university offering a position in a multidisciplinary environment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences earth and related environmental sciences environmental sciences
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences genetics genomes
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BUDAPEST
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.