Objective
The goal of this proposal is to create a stroke biobank to identify genes that influence the risk fordeveloping stroke, also called susceptibility genes. Stroke is the third leading cause of death in thedeveloped world. It is even more disabling than letha l, and the persistent neurological impairment andphysical disability caused by stroke have a substantial socioeconomic cost. Stroke is a complexdisease resulting from the interplay of environmental and genetic factors. Major known risk factorsinclude famil y history, age, hypertension, hypercholesterolemia, diabetes, cardiovascular disease,smoking and alcohol consumption. Identification of genes increasing susceptibility to stroke wouldhave far-reaching public health impact, from enhancing motivation to make behavioral and lifestylechanges in susceptible individuals to providing basic biological and clinical information about thedevelopment, prevention and treatment of stroke.The genetic component has been demonstrated in twin and family studies, in animal mo del studies,and mutations have been found in several genes in rare classical Mendelian forms of stroke. However,very few susceptibility genes specific for the common forms of stroke have been identified andassociation studies have mostly reported conflicti ng results. We wilt use a novel genomic convergenceapproach that combines genomic screening, expression analysis, and association studies to identifysusceptibility genes.The first and key step in this endeavor is the creation of a high quality stroke bioba nk. During thetwo years of this grant we specifically propose to:1. Define the participating criteria (e.g. inclusion and exclusion criteria) and the information to becollected (e.g. clinical history and environmental exposures).2. Collect the biological s amples and information from 800 individuals originating from 200Portuguese multiplex families with ischemie stroke, CADASIL and cavernous#
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- social sciences sociology family studies
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.