Objective
The continuously rising prevalence and incidence rates of end stage renal disease (ESRD) in Europe represent a serious public health problem. Patients with ESRD exhibit a tremendously increased mortality due to cardiac disease (CD) compared to the age matched general population. Although the CD-protective effects of Angiotensin-Converting Enzyme Inhibitors (ACEI) and AT1 Receptor Blocker (ARB) are generally accepted in high-risk populations, only scarce data exist for patients with ESRD treated by renal transplantation. To extrapolate the effectiveness of ACEI/ARB on CD prevention to ESRD patients may not be appropriate, since it has recently been shown that some of the traditional CD risk factors such as arterial hypertension, hypercholesterolemia or body mass index are even negatively associated with CD events and mortality in ESRD patients. Similarly, the effectiveness of these drugs on transplant survival remains elusive. Therefore the applicant will elucidate the specific issue of whether the use of ACEI or ARB in ESRD is associated with patient and transplant survival.
The Austrian/Eurotransplant databases will be utilized to answer the proposed issues, since the few large renal transplant databases UNOS, USRDS or CTS do not contain a complete follow up of important CD risk factors and medication. Sample size calculations revealed the feasibility of the proposed research. The actual analysis of the data will be performed at the Harvard School of Public Health under the supervision of Dr. G. Curhan, faculty in the epidemiology department. Starting in summer 2004, the applicant will receive three months of thorough training in clinical epidemiology at the HSPH and among completion starting with the analysis of the proposed project. After conclusion of the study in end 2005, the applicant will return to his home institution to conduct further studies and use the gained expertise to set up a training program in clinical effectiveness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences health sciences public health epidemiology
- medical and health sciences clinical medicine nephrology
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.