Objective
Transplantation is often the only therapy for end-stage organ failure. The number of patients for whom this surgery is indicated is increasing but the number of available organs has remained relatively constant and waiting lists are growing. At present over 17,000 patients in the UK and Eurotransplant zones, which contain some 170 million people, are waiting for organ transplantation. The early success of transplant surgery is impressive with more than 80% of heart, kidney and liver grafts surviving for more than one year.
However, most transplanted organs undergo a process of chronic rejection, which results in failure of more than half within 6-10 years. Chronic graft loss is now regarded as the greatest socio-economic problem associated with otherwise high ly successful transplant surgery. Few groups study the processes, which result in chronic graft loss and ours is almost unique in Europe in its capacity to provide comprehensive research training in this critical area. Our group in Newcastle combines non-clinical scientists with clinical academics from one of the largest and most comprehensive transplant programmes in Europe to produce a training environment, which has successfully helped 24 science and clinical trainees to achieve higher research degrees in the last 8 years.
This proposal builds on a research hypothesis our group has developed recently to explain certain features of the chronic graft rejection process and will provide training opportunities for 4 EST candidates working in individually defined but complementary research areas. Of course, we hope that the results from these projects will directly combine to suggest novel therapeutic strategies to benefit European and global transplant recipients. However, we are entirely confident that our EST students will be inspired to develop future research programmes in this important area as they develop their careers within the European Research Area.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine transplantation
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-2
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NEWCASTLE UPON TYNE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.