Objective
Reciprocal interactions between oral ectodermal and ectomesenhymal cells play crucial role in the guidance and control of the processes of tooth initiation, morphogenesis, and hard tissue formation. Less is known about signal molecules regulating the differentiation of ameloblasts, which produce the enamel. In Thesleff s laboratory there are transgenic mouse models, which can provide novel tools for analysis of the molecular regulation of ameloblast function. The continuously growing mouse incisor provides an excellent model system where the maintenance as well as advancing differentiation of stem cells can be monitored. Analysis of the molecules involved in stem cell maintenance and differentiation can be expected to share similarities in different organs, and hence this work will be of general importance in the area of stem cell research.
The main goal of the planned research is to learn to understand the formation of dental enamel: we will analyse how the cells producing enamel differentiate from stem cells in the dental epithelium. We will also focus on the role of signal molecules in regulation of ameloblast differentiation. Finally, we try to develop a cell culture model for ameloblast precursor differentiation, which could be used for enamel matrix production in the future.
The understanding of the cues stimulating enamel formation can perhaps be used in the future for means for enamel regeneration and lead to new ways to produce this important biomaterial. Enhancing our knowledge on the stem cell biology is pivotal, e.g ., for successful release of appropriate molecules to improve tissue healing or to promote regeneration of oro-facial tissues. In general, the consequences of this information can have important implications and commercial applications via developing novel clinical approaches such as forced periodontal regeneration using enamel extracts and replacement of damaged oral structures by using tissues developed from stem cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HELSINGIN YLIOPISTO
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.