Objective
The contamination of seafood with algal toxins can cause severe neuronal and gastrointestinal disorders but also allergies in human. Sporadic outbreaks of poisoning by ingestion of shellfish which have accumulated marine biotoxins have become a world-wide problem. The economic consequences caused by the production of marine biotoxins during algal blooms in the coastal regions are enormous. In this project, fast, simple and cost-effective detection methods for marine biotoxins in seafood as well as patient sera will be developed, based on the application of high-affinity capture antibodies and novel artificial receptor mimics against the toxins. The applicants already succeeded in raising antibodies against okadaic acid, a diarrhetic shellfish poisoning (DSP) toxin. This promising strategy will now be extended to other groups of relevant toxins causing paralytic shellfish poisoning (PSP), neurotoxic shellfish poisoning (NSP) or amnesic shellfish poisoning (ASP). The new tools for the detection (and quantification) of marine biotoxins developed in the proposed project are based on the application of the new Polymer Instruction technology and the highly sensitive Integrated Optical Grating Coupler (IOGC) biosensor technology, and the use of high-affinity antibodies for sensitive ELISA und Western blotting techniques based on an infrared-fluorescence imaging system. User-friendly chip (POCT Chip, dip-stick/card test) assay methods as well as new bioassays based on interaction of okadaic acid with phosphoprotein phosphatase 2A (colorimetric microtitre-plate based PP2A inhibition assay) or the activation/phosphorylation of MAP kinase p38 will be developed. The developed technologies will be compared with existing techniques for evidence of improved efficiency and accuracy. Prototype kits will be manufactured by the companies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- natural sciences chemical sciences polymer sciences
- medical and health sciences clinical medicine allergology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-FOOD-2-A
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MAINZ
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.