Objective
Colorectal cancer is a leading cause of cancer in European non-smokers. Dietary changes might reduce the incidence up to 70%, according to epidemiological reports, but the dietary factor initiating them is not known. Researchers in the proposed outgoing organisation have recently found that rats given a diet with reduced thiamin (vitamin B1) for 4 months have small patches in their colons, ACF, that are recognised as precursors to colon cancer (Bruce et al, Cancer Lett. 2003). Furthermore, they have found with studies in tissue culture that the toxic effects of reduced thiamin are markedly worse when the cells are exposed to an oxidative stress (Shangari et al, Biochem. Soc. Trans. 2003).
We want to use these preliminary findings as a base to find out whether the combination of reduced thiamin and an oxidative stress from cooked food increases the formation of ACF in the colons of rats at 4 months and whether it will result in colon cancer if extended for a longer period. This will be extended to other natural sources of oxidative stress such as red meat and sucrose. We also want to investigate biochemical measures from blood samples from these animals that can be used as biomarkers of thiamin deficiency and oxidative stress. The final stage would be to correlate biomarkers with the development of colon carcinogenesis in vivo. Our expectation is that these diet changes, reduced thiamin and cooked food, will result in colon cancer in the rat, and that the biochemical measures associated with the development of the tumours can be used to assess this risk in humans.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences health sciences nutrition
- natural sciences chemical sciences organic chemistry heterocyclic compounds
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.