BIONEL is a Marie Curie EST site at Lund University involving Analytical and Biochemistry/Biotechnology/Applied Microbiology/Cell-Organism/Neural Stem Cell Biology/Restorative Neurology/Solid State Physics. The aim is to provide early stage research traini ng in Bioanalytical Chemistry/Bionanotechnology/Bioelectrochemistry for stays from 9 months to a full PhD. The scientific content can be summarised as: Global parameters such as bioavailability/toxicity can only be assayed using living cells. The determina tion of these parameters motivates the objective of this project: to develop tools to monitor dynamic cellular processes with electrochemistry through (i) development of amperometric and impedance procedures for monitoring cell membrane integrity, redox si gnalling, and exocytosis. Focus will be at obtaining and understanding mediated and (possibly direct) electrochemical communication with both pro-and eukaryotic cells (ii) development of nano-Interdigitated Electrodes (IDE) for characterisation of exocytos is of catecholamine neurotransmitters from neurons, (iii) elaboration of methods for stem cell differentiation into different phenotypes by monitoring exocytosis using IDE arrays, (iv) encapsulation of cells into layer-by-layer built polymers for cell stab ilisation and self-assembling on IDEs, (v) development of cell and tissue based arrays. All fellows will work in projects involving at least two different disciplines under supervision of full and/or associate professors and with state-of-the-art equipment . Additional training in presentation skills, undergraduate supervision, safety, management will be provided. As a result of the training, all fellows will be able to publish scientific papers in peer reviewed international periodicals. The infrastructure will be open for the fellows with access to Internet, e-mail, remote databases etc. as well as advanced and graduate courses.
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