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Design of new nucleosides for DNA interactions and fluorescent studies

Objective

The strategy of replacing DMA natural bases by non-polar surrogates has opened ways to add new functions to the DNA structure, to probe protein-DNA interactions, to test DMA repair enzymes, to stabilize structure, and to probe the internal features of the helix. Also, different fluorescent species named fluorosides, which have been shown an increasingly useful tool for bio-molecular analysis and is applied widely in the biosciences.

This project wants to develop a new series of nucleosides with different characteristics. One group will have different steric demanding nucleosides which will be used to study the interaction with DNA polymerase enzyme and the other group will have fluorescent activity which will be evaluated as a molecular tags.

Call for proposal

FP6-2002-MOBILITY-6
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Funding Scheme

OIF - Marie Curie actions-Outgoing International Fellowships

Coordinator

UNIVERSIDAD AUTÓNOMA DE MADRID
Address
Ctra. De Colmenar Km 15, Cantoblanco
Madrid
Spain

Participants (1)

DEPARTMENT OF CHEMISTRY STANFORD UNIVERSITY
United States
Address
107 Stauffer L Building
Stanford