Objective
Dr. Sebastien Gouin, a French national who has completed his PhD is requesting funds for 1 year to work in Ireland with Dr. Paul V. Murphy to synthesise glycoclusters for biological evaluation. It is proposed that he will receive training in glycoconjugate synthesis and purification, NMR in determination of structure, mass spectrometry to study lectin clustering as well as gain exposure to other biological evaluations. This will diversify the expertise of the applicant who has worked previously on the synthesis of chelating agents for radioelements. Sebastien's PhD work provided a first approach to the principles of molecular design and chemical biology.
This consisted of the synthesis of radiopharmaceuticals, in particular of bifunctional chelating agents ( BCA). BCAs bearing aminocarboxylate functions, permit the complexation of radioelements and are suitable for nuclear medicine applications. The BCA also possess an active terminal allowing coupling to a specific biologic vector. Sebastien confirmed the complexation properties of his new ligands by labelling with different radioelements. Tests performed on the resulting complexes indicate that rigid and semi-rigid skeletons (pre-organization concept) are of considerable interest for the affinity of the radioelements. During the course of his PhD, completed at the University of Nantes (FR), the applicant gained experience in synthetic procedures and analytical techniques for investigation of the complexing abilities of new ligands.
Many fundamental aspects of in teraction of glycoclusters with lectins and the consequences of these interactions are not understood. Advances could lead to development of new tools for biology or drugs for medicine. Dr. Murphy's group in Dublin have developed restricted multivalent gly cosyl amide scaffolds for clustering receptors in solution and have published three papers to date on this topic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences organic chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.