Objective
In the last years cross correlation rates have been shown to be an avenue to investigate molecules with large molecular mass and to increase NMR performances in structural biology. Another perspective breakthrough is the direct detection of 13C and/or 15N n uclei. The project will develop new approaches based on the direct detection of 13C to measure cross correlation rates to push NMR frontiers in the investigation of large macromolecules. The focus of the project will be the understanding of the functional properties of CutA1 proteins. CutA1 are a family of copper binding proteins, occurring in different organisms, which are supposed to fulfil different functions in bacteria and in mammals. The protein in solution is a trimer of 12.000 MW each subunit and the multimeration seems to be copper-dependent.
The study of 36000MW copper protein in the oxidized paramagnetic form represents a challenge for NMR methodologies currently available. This project has both an academic and an industrial interest. On one hand, t he improvement of the NMR methodology, here proposed, will increase the capability of NMR to solve biological problems. On the other hand, all the techniques that will be developed will be applicable in the pharmaceutical industry (high throughput screening and drug design). Apart from the scientific objectives that are extensively explained in the project proposal, there is always an educational objective: forming a young scientist as a qualified NMR spectroscopist.
This training will be possible only within a work frame like that available at CERM: i.e. a large-scale laboratory with qualified personnel and excellent facilities. The expertise acquired during this project will allow the young researcher to tune this methodology in one of the structural biology laboratories in Spain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences biological sciences biochemistry biomolecules proteins protein folding
- natural sciences biological sciences zoology mammalogy
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SESTO FIORENTINO (FLORENCE)
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.