Objective
Telomerase, a ribonucleoprotein complex responsible for the maintenance of telomeres, is significantly expressed in 90% of cancer cells and apparently absent in normal somatic cells. Expression of the catalytic protein component of this telomerase complex, hTERT (human Telomerase Reverse Transcriptase), seems to be the limiting factor for telomerase activity, and plays a fundamental role in cellular immortalisation. Moreover, increasing observations indicate that hTERT protein could also have an anti-apoptotic function, independently from its role in telomere elongation.
The knowledge of the factors and mechanisms controlling hTERT expression would be highly significant to understand the telomerase re-activation process, a key step during immortalisation and onco-genesis in human cancers. At this date, few transcriptional factors are known to bind hTERT promoter but their actual contribution in telomerase regulation are not demonstrated. Moreover, published data from different laboratories indicate that important relevant transcription factors have not yet been identified.
Thus, the factors and mechanisms controlling the hTERT transcription still remain to be elucidated during physiological processes. Using our unique cellular model, in which telomerase can be regulated by several means by a physiological agent, all-trans retinoic acid, we propose to use a cDNA microarray approach to identify and select genes that could be specifically involved in hTERT regulation. In continuation, we will use a functional genomics approach to assess their actual contribution in that process. Our experiments would contribute to a better understanding of hTERT regulation mechanisms, and could also be important for the identification of new target genes for anti-cancer therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BERGEN
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.