Objective
Asymmetric mRNA localization is a common posttranscriptional method by which cells target proteins efficiently to their site of function. In most cases, the destination of mRNAs is determined by an interaction between RNA and trans-acting factors. However, i t is unclear which trans-acting factors are universally required for mRNA export and whether different export factors may have specialized roles in the transport and localization of subpopulations of mRNAs and/or at different times or tissues in development.
In the proposed project, we will focus on the role of mRNA nuclear export factors inmRNA localization in the cytoplasm. Members of this family include the "nuclear export factors"(NXFs) and their cofactors. Some NXFs and their cofactors are involved in general export of all RNAs, such as NXF1 or Aly/Refl. In culture cells, an accumulation of polyadenylated RNAs isobserved when NXF1 or Aly/Refl are depleted. In higher eukaryotes, the diversity of mRNA nuclear export factors suggests the involvement of these t rans-acting factors in other mechanisms than the nuclear export.
These alternative mechanisms can be in relation with the transport, localization, anchoring or/and translation of mRNA in the cytoplasm. Interestingly in Drosophila, our unpublished data shows t hat NXF2 is required for dorso-ventral axis specification, suggesting a role in gurkenmRNA localization. We will use a targeted genetic screen to study the role of each component inmRNA transport and/or localization. We expect that this study will allow us to understand how generalmRNA export factors are required in the cytoplasm for mRNA localization.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.