Objective
The African trypanosome Trypanosoma brucei causes African sleeping sickness and the cattle disease nagana. The human and socio-economic impact of these diseases is considerable. The available drugs for humans are inadequate and difficult to administer. Parasites are very dependent on glycoconjugates for their survival and infectivity. The main goal of this project is to determine the function of genes involved in galactose-containing glycoconjugate biosynthesis and processing in T. brucei.
The emerging T. bruce i genome will be systematically mined, and the candidate genes classified in different glycosyltransferase (GT) groups. Representative examples of these putative GTs will be experimentally examined by inducible RNAi knock-downs, by gene knockout, or by construction of tetracycline-inducible conditional null mutants. Mutant cells will be assessed for growth in vitro and for infectivity in vivo. Moreover, mutant cells will be bio-chemically phenotyped in both the blood stream and procyclic lifecycle forms of the parasite. In this way, we should be able to assign precise functions to genes and thus, identify sequence motifs/patterns that discriminate between different families of parasite enzymes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry sleep disorders
- agricultural sciences animal and dairy science domestic animals animal husbandry
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
- DUNDEE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.