Objective
The major hallmarks of almost all cancers are aneuploidy, deregulation of the cell cycle and the reactivation of telomerase. While telomerase expression as been widely shown to ensure chromosomal stability, telomere dysfunction can be made responsible for a neuploidies universally found in cancers. Aneuploidy develops early in tumour development while telomere dysfunction is mostly found at the end of cellular life span and might induce aneuploidy directly when checkpoint functions at the end of the life span a re abrogated. This proposal addresses how the last cell cycle transitions are monitored by the cell cycle checkpoints and how loss over control of these may lead to aneuploidy.
We are proposing to study the DNA damage response in normal cells that have one or more short telomeres at replicative senescence and to elucidate whether different threshold levels trigger different responses. Furthermore we propose to study the chromosomal changes in cells that have abrogated checkpoints at replicative senescence and analyse if a common tetraploidy intermediate promotes the elimination of genes that suppress cell growth and amplifies those that are associated with growth advantage, including telomerase. Our major goal is to better understand the relationship between short telomeres and the induction of genomic instability that leads to carcinogenesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.