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Bio-based functional materials from engineered self-assembling peptides

Objective

The BASE-STREP aims at advancing the science and technology of sustainable and functional materials. Specifically it targets innovative nano-coatings for plastics, metals and ceramic objects, exploiting the self- assembly capabilities of short (< 25) am ino-acid sequences (=peptides) in industrially relevant applications. Self- assembly is a method of spontaneous organisation of molecules into higher order structures and defined by set boundary conditions (e.g. pH, T, etc).This addresses the need for wate r based coating solutions beyond plastics and explores principles of nature for supramolecuar structure formation at various surfaces. These ambitions require a work programme addressing the challenges facing peptide based nano-coatings in terms of their b io-technological engineering at a cost of < 300 Euro /kg and their functional performance validation in selected self-assembled nano-coatings. The workplan covers: 1 .Laboratory solid-phase synthesis of known peptides and their evaluation 2.Experimental biosynthetic production of two peptides at laboratory (1-3L) scale and the development of efficient scale-up protocols 3.Exploring the coating capacity of tailored peptides for various substrates and environmental conditions. 4.Biotechnical production and scaling up the production of one peptide to 100 L 5.Functionality evaluation of a specific peptide for selected multi-sectorial applications targeted by the industrial partners. 6.Either production at 1000 L scale (aiming at kg quantities), or production of a second peptide in g to hg quantities to allow larger scale performance evaluation of nano-coatings on selected substrates 7.A sustainability study to assess the environmental, economic and societal impact of these novel applications. BASE brings toget her a diverse, highly skilled group from large industry (Dow,P&G), SME (MARE, SupraPolix, Interchem Hellas), research institutes (A&F, CIDETEC), and academia (Ghent, Leeds, Stuttgart).

Call for proposal

FP6-2003-NMP-TI-3-MAIN
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Funding Scheme

NoE - Network of Excellence

Coordinator

DOW BENELUX B.V.
Address
Herbert H. Dowweg 5
Terneuzen
Netherlands

Participants (10)

AGROTECHNOLOGY AND FOOD LNNOVATIONS B.V.
Netherlands
Address
Bornsesteeg 59
Wageningen
FUDAN UNIVERSITY
China
Address
220 Handan Road
Shanghai
FUNDACIÓN CIDETEC
Spain
Address
Parque Tecnológico De Miramón, Paseo Miramón, 196
San Sebastián
LNTERCHEM HELLAS S.A.
Greece
Address

Vathi Avlidos - Evia
MARE ENGINEERING SRL
Italy
Address
Via Tarantino 12
Napoli
PROCTER & GAMBLE EUROCOR N.V.
Belgium
Address
Temselaan 100
Strombeek-bever
SUPRAPOLIX BV
Netherlands
Address
Horsten 1
Eindhoven
UNIVERSITAET STUTTGART
Germany
Address
Keplerstr. 7
Stuttgart
UNIVERSITEIT GENT
Belgium
Address
Sint-pietersnieuwstraat 25
Gent
UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
Leeds