Objective
Inflammatory disorders are considered to be the underlying cause of at least 50 different diseases, many of which are disabling or even fatal, i.e. heart attack, rheumatoid arthritis, asthma and stroke. Current therapies are mainly treating symptoms and not the basic disease mechanisms and many of them have disturbing side effects.
In the proposed project a strategic partnership will be formed between a Swedish biotech SME, AlligatorBioscience AB, and an academic partner, the Eijkman Winkler Institute at University Medical Centre in Utrecht. Alligator specialises in development of protein based drug candidates. The unique asset of the company is the proprietary protein engineering technology FIND (Fragment INduced Diversity), which is speedy and makes it feasible to develop drugs from starting material so far not appropriate for human use. UMCU has frontline expertise in the interaction between bacteria and the human immune system, and in highly specialised cell based functional assays and animal models.
The immediate objective of the project is to pursue two different approaches to develop novel drug candidates for the treatment and basic disease modification of inflammatory disorders. The first involves de-immunisation of an already identified molecule (CHIPS) derived from Staphylococci, the second involves development of small antibody fragments that mimic the CHIPS action. The CHIPS molecule was developed by UMCU, and the group has also shown the therapeutic potential of the substance.
Further development has however so far been abandoned because of a strong immune response elicited by the molecule. The combined efforts and expertise areas of the two partners will now make a new development possible. As a long term objective the collaboration will provide both partners with technologies and a scientific contact network that will promote their future development and scientific as well as commercial competitiveness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine pneumology asthma
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.