Skip to main content

European systems biology initiative for combating complex diseases

Final Report Summary - ESBIC-D (European systems biology initiative for combating complex diseases)

The ESBIC-D project linked together groups from some of the largest European cancer research organisations and centres, as well as resources of leading clinical research groups in Europe with expertise in high-throughput functional genomics and in computational and systems biology resources with the aim of establishing a European framework for a systems biology approach to combat complex diseases using cancer as a prototypical problem.

The project main goals were to integrate data resources and analysis tools available at the participating centres and at other centres worldwide, to develop and use new mechanisms to identify the pathways likely to be most relevant to the problem domain (cancer), to incorporate these into the models, and to carry out benchmarking studies into the pilot scale to identify strength and weaknesses of current approaches. A major effort would also be invested in an outreach component, specifically designed to create local networks contributing to the work of each centre, and to educate researchers throughout Europe concerning the new possibilities and concepts.

The project partners contributed several unique elements that would ultimately strengthen systems biology approaches in general and disease-oriented research in particular:
-strategies for the coordinated network analysis of patient samples with respect to clinical parameters, molecular pathways and high-throughput technology;
- strategies for the analysis of time course data with respect to marker identification and the reconstruction of regulatory modules;
- annotation, exchange and kinetic analysis of models for cancer-related pathways;
- strategies how to generate predictions from realistic disease-relevant reaction networks;
- training network and workshop series between the partner organisations;
- creating a European Union-wide network for apoptosis research.

Related documents