Objective
For this effort all top European cancer research groups working on the association between defects in the tricarboxylic acid cycle (TCAC) and cancer form a consortium to 1) profoundly characterize the human phenotypes to enable identification and efficient cancer prevention, and 2) to unravel the underlying molecular mechanisms. Recent breakthrough findings by the consortium participants and others have shown that defects in at least four TCAC genes - fumarate hydratase (FH, fumarase), and succinate dehydro genase (SDH) B, C, and D - can confer susceptibility to cancer. We shall take these studies forward by characterizing the natural history of the syndromes in large European materials. Simultaneously, we shall perform functional studies to elucidate the cel lular events induced by these defects by systems biology approaches including functional studies in cell lines, model organisms, and transcription profiling of TCAC deficient and proficient tumors and models. TCAC defect associated expression patterns will be utilized to examine other cancer types for such defects. We have evidence that modifying genes play a key role in TCAC defect associated tumorigenesis, and candidate regions have been identified. Following gene identification, the possible role of thes e modifiers in low penetrance cancer predisposition in the general population will be examined. The rationale to form this consortium is simple and strong. The consortium brings together the key European cancer researchers studying TCAC associated tumorige nesis. Studying separately the tumorigenic effects of FH and the different units of SDH would be ineffective, and formation of the consortium will ensure that Europe will maintain the initiative in this new and exciting field of research. The deliverables arising from the workpackages will contribute to the common goals; prevention of TCAC associated cancers, and learning the lessons these lesions can teach to cancer #
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HELSINGIN YLIOPISTO, HELSINKI
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.