Objective
Our objective is to develop therapeutic anti-cancer vaccines that provide a clinical benefit to 40% of the vaccinated patients. This threshold, if reached in the absence of serious toxicity, would qualify immunotherapy as an additional standard treatment for cancer. To reach this objective, our project comprises three major activities. A first part of the project consists in clinical trials of vaccination, to compare various vaccines such as peptides and RNA, with different types of immunological adjuvants, and dendritic cells. Safety and clinical efficacy will be the primary endpoints of these trials. A large effort will be devoted to monitoring the anti-vaccine T cell responses, as examining the correlation between immunological and clinical response s to the vaccines will be crucial to understand which factor(s) limit tumour regression.
A second part of the project, tightly connected to the clinical trials because it uses biological material from the vaccinated patients, consists in optimising tumour vaccines and combating immune evasion. Foreseeable mechanisms of tumour escape will be analysed and correlated with the clinical results. Improved modalities of vaccination will be tested, and new target antigens will be identified. All these results will help to design improved vaccines. Finally, considering the complexity of mechanisms that may lead to or prevent tumour regression in vaccinated patients, we propose to explore more fundamental aspects of the anti-tumour immune response. This includes the cross presentation of tumour antigens by dendritic cells, recruitment of cells of the innate immune system, involvement of suppressor T cells, and development of murine models of inducible tumours. If new concepts emerge from this work, they will also help t o design better vaccines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
- medical and health sciences basic medicine immunology immunotherapy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
UCL 75.50 BRUXELLES
Belgium
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Participants (23)
TÜBINGEN
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PARIS
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ZÜRICH
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OXFORD
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2040 ROTTERDAM
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9101 NIJMEGEN
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GRANADA
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HEIDELBERG
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BERLIN
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9600 LEIDEN
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MILAN
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ERLANGEN
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BRUSSEL
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MARSEILLE
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MILAN
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NANTES
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TUEBINGEN
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GRENOBLE
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MAINZ
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PARIS
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MAINZ
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130 BRUXELLES
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PARIS
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